UCLA Essay Example | Topics and Well Written Essays - 750 words

UCLA - Essay Example However, the magnitude of the compromised ethics on the situations differs from one segment to the other. Among the five segments the most ethically compromised situation is act two in which the two businesses talked about have a silent partner. One of the businesses, Chad’s business has Chad as a business partner. This results to unethical undertakings like placing his picture on the business and wearing t-shirts with his name and yet he is dead. The action sets superstition that causes it to be unethical thus influencing the running of the business. Unlike other situations where few individuals compromise ethics, in this segment all the individuals involved in the business compromise ethics. Everybody was wearing a shirt with Chad’s name; the activity of every person involved was shaped by Chad who died before the business started. This makes the segment ideal for explaining an ethically compromised situation. Family businesses are very different in characteristics when compared to other types of businesses. One of the characteristics that makes them unique is that they require succession after a certain period. The business is passed from an incumbent senior generation to a next generation of leadership or ownership (Ward 3). This provides a challenge and opportunities that are rare in other kinds of businesses. Another thing that makes family business rather unique is that unlike the public companies owned by investors who are the main shareholders, this business has an individual owner or a team of owners who are family members. According to Gersick (1), these owners play a very different role from that played by shareholders. They directly influence the running of the business and general performance of the employee of that business which is not the role of the shareholders in the public companies. Family ties prohibit a person from doing certain things to certain members of his family. Private enterprises

Methodology for albinism Essay Example | Topics and Well Written Essays - 1000 words

Methodology for albinism - Essay Example The condition is defined as "a group of congenital heterogeneous disorders in which there is either complete or partial absence of pigment in the skin, hair and eyes because of the absence of or a defect in an enzyme involved in the production of melanin" (Park et al, 2011). The pattern of inheritance of albinism is variable. It can be X-linked, autosomal dominant or autosomal recessive. It is mainly autosomal recessive in oculocutaneous albinism (Park et al, 2012). Clinical presentation is at birth and depends on the type of oculocutaneous albinism. There are basically ten types of oculocutaneous albinism of which four are common and merit importance. They are oculocutaneous albinism: type 1A, type 1B, type 2, type 3 and Hermansky–Pudlak syndrome (Park et al, 2012). The methodology of oculocutaneous albinism is clearly understood. In this essay, the methodology of oculocutaneous albinism will be discussed. Methodology Albinism is a genetic disorder that is hereditary. Genetic disorders are those conditions in which alteration of a specific gene leads to abnormal enzyme or protein production, leading to clinical manifestations. The main pathogenesis in albinism is abnormal synthesis or distribution of melanin. Melanin is a pigment that is responsible for the coloration of eyes, skin and hair. It is a protein and is synthesized in melanocytes from tyrosine, an aminoacid. Melanocytes are present in the skin, hair bulbs and eyes. The synthesis takes place in specialized organelles known as melanosomes. The most important enzyme in the production of melanin is tyrosinase. This enzyme converts tyrosine to dopa. The gene for tyrosinase is located in the chromosome 11. Mutations in the locus concerned with tyrosinase enzyme can lead to defective or absent tyrosinase. This can result in complete or partial absence of pigmentation of the skin, hair and eye. This type of oculocutaneous albinism is type-1. When the defect lies in P-polypeptide, which is a transport er for melanosomal tyrosine, type-2 oculocutaneous albinism arises. Tyrosinase is present in this type. Its functioning is also normal. But, the transporter is defective leading to the disease. The P gene is in chromosome 15. Patients with type-2 oculocutaneous albinism have some pigmentation, but it is lighter. Epithelial pigmentation of the retinal pigment around the macula is necessary for normal foveal development. Dopa, derived from tyrosine is essential normal retinal development as it is a mitotic agent. Lack of dopa leads to foveal hypoplasia and this can lead to decreased visual activity. Eventually the optic nerve fibers decussate abnormally and this leads to strabismus and monocular vision. Transillumination defects due to depigmented iris result in photophobia (Wei et al, 2011). In type-1 A, the clinical presentation is obvious at birth and the baby is born with blue-grey irides, light pink colored skin, depigmented white hair and predominant red reflex (Wei et al, 2011) . As the infant grows more symptoms related to eyes become obvious. These include nystagmus, decreased vision, strabismus, monocular vision and poor stereopsis. The skin can never develop pigmented lesions even after prolonged exposure to sunligh